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TREATMENT WITH FLT3 INHIBITOR IN PATIENTS WITH FLT3-MUTATED AML IS ASSOCIATED WITH DEVELOPMENT OF SECONDARY FLT3-TKD MUTATIONS
BACKGROUND: FLT3-internal tandem duplication (ITD) mutations are found in approximately 30% of AML patients. FLT3 inhibitors have shown clinical activity in AML with FLT3-ITD but responses are usually short lived. METHODS: We reviewed 69 FLT3 mutated AML patients, treated with different FLT3 inhibit...
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| Main Authors: | , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4124083/ https://ncbi.nlm.nih.gov/pubmed/24737502 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cncr.28705 |
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