Detectable FLT3-ITD or RAS mutation at the time of transformation from MDS to AML predicts for very poor outcomes

BACKGROUND: The molecular events that drive the transformation from myelodysplastic syndromes (MDS) to acute myeloid leukemia (AML) have yet to be fully characterized. We hypothesized that detection of these mutations at the time of transformation from MDS to AML may lead to poorer outcomes. METHODS...

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Foilsithe in:Leuk Res
Main Authors: Badar, Talha, Patel, Keyur P, Thompson, Philip A, DiNardo, Courtney, Takahashi, Koichi, Cabrero, Monica, Borthakur, Gautam, Cortes, Jorge, Konopleva, Marina, Kadia, Tapan, Bohannan, Zach, Pierce, Sherry, Jabbour, Elias J, Ravandi, Farhad, Daver, Naval, Luthra, Raja, Kantarjian, Hagop, Garcia-Manero, Guillermo
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2015
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Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4822515/
https://ncbi.nlm.nih.gov/pubmed/26547258
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.leukres.2015.10.005
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