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Detectable FLT3-ITD or RAS mutation at the time of transformation from MDS to AML predicts for very poor outcomes

BACKGROUND: The molecular events that drive the transformation from myelodysplastic syndromes (MDS) to acute myeloid leukemia (AML) have yet to be fully characterized. We hypothesized that detection of these mutations at the time of transformation from MDS to AML may lead to poorer outcomes. METHODS...

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מידע ביבליוגרפי
הוצא לאור ב:	Leuk Res
Main Authors:	Badar, Talha, Patel, Keyur P, Thompson, Philip A, DiNardo, Courtney, Takahashi, Koichi, Cabrero, Monica, Borthakur, Gautam, Cortes, Jorge, Konopleva, Marina, Kadia, Tapan, Bohannan, Zach, Pierce, Sherry, Jabbour, Elias J, Ravandi, Farhad, Daver, Naval, Luthra, Raja, Kantarjian, Hagop, Garcia-Manero, Guillermo
פורמט:	Artigo
שפה:	Inglês
יצא לאור:	2015
נושאים:	Article
גישה מקוונת:	https://ncbi.nlm.nih.gov/pmc/articles/PMC4822515/ https://ncbi.nlm.nih.gov/pubmed/26547258 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.leukres.2015.10.005
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Detectable FLT3-ITD or RAS mutation at the time of transformation from MDS to AML predicts for very poor outcomes

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