Detectable FLT3-ITD or RAS mutation at the time of transformation from MDS to AML predicts for very poor outcomes

BACKGROUND: The molecular events that drive the transformation from myelodysplastic syndromes (MDS) to acute myeloid leukemia (AML) have yet to be fully characterized. We hypothesized that detection of these mutations at the time of transformation from MDS to AML may lead to poorer outcomes. METHODS...

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Bibliografski detalji
Izdano u:Leuk Res
Glavni autori: Badar, Talha, Patel, Keyur P, Thompson, Philip A, DiNardo, Courtney, Takahashi, Koichi, Cabrero, Monica, Borthakur, Gautam, Cortes, Jorge, Konopleva, Marina, Kadia, Tapan, Bohannan, Zach, Pierce, Sherry, Jabbour, Elias J, Ravandi, Farhad, Daver, Naval, Luthra, Raja, Kantarjian, Hagop, Garcia-Manero, Guillermo
Format: Artigo
Jezik:Inglês
Izdano: 2015
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Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4822515/
https://ncbi.nlm.nih.gov/pubmed/26547258
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.leukres.2015.10.005
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