Identification of Novel Germline Polymorphisms Governing Capecitabine Sensitivity

BACKGROUND: Capecitabine, an oral 5-fluorouracil (5-FU) prodrug, is widely used in the treatment of breast, colorectal, and gastric cancers. To guide selection of patients potentially at greatest benefit of experiencing antitumor efficacy, or, alternatively, of developing toxicities, identifying gen...

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Hlavní autoři: O’Donnell, Peter H., Stark, Amy L., Gamazon, Eric R., Wheeler, Heather E., McIlwee, Bridget E., Gorsic, Lidija, Im, Hae Kyung, Huang, R. Stephanie, Cox, Nancy J., Dolan, M. Eileen
Médium: Artigo
Jazyk:Inglês
Vydáno: 2012
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3413892/
https://ncbi.nlm.nih.gov/pubmed/22864933
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cncr.26737
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