Identification of Novel Germline Polymorphisms Governing Capecitabine Sensitivity

BACKGROUND: Capecitabine, an oral 5-fluorouracil (5-FU) prodrug, is widely used in the treatment of breast, colorectal, and gastric cancers. To guide selection of patients potentially at greatest benefit of experiencing antitumor efficacy, or, alternatively, of developing toxicities, identifying gen...

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Main Authors: O’Donnell, Peter H., Stark, Amy L., Gamazon, Eric R., Wheeler, Heather E., McIlwee, Bridget E., Gorsic, Lidija, Im, Hae Kyung, Huang, R. Stephanie, Cox, Nancy J., Dolan, M. Eileen
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3413892/
https://ncbi.nlm.nih.gov/pubmed/22864933
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cncr.26737
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