N-methylpurine DNA glycosylase inhibits p53-mediated cell cycle arrest and coordinates with p53 to determine sensitivity to alkylating agents

Alkylating agents induce genome-wide base damage, which is repaired mainly by N-methylpurine DNA glycosylase (MPG). An elevated expression of MPG in certain types of tumor cells confers higher sensitivity to alkylation agents because MPG-induced apurinic/apyrimidic (AP) sites trigger more strand bre...

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Main Authors: Song, Shanshan, Xing, Guichun, Yuan, Lin, Wang, Jian, Wang, Shan, Yin, Yuxin, Tian, Chunyan, He, Fuchu, Zhang, Lingqiang
Formáid: Artigo
Teanga:Inglês
Foilsithe: Nature Publishing Group 2012
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Original Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3411163/
https://ncbi.nlm.nih.gov/pubmed/22801474
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cr.2012.107
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