N-methylpurine DNA glycosylase overexpression increases alkylation sensitivity by rapidly removing non-toxic 7-methylguanine adducts

Previous studies indicate that overexpression of N-methylpurine DNA glycosylase (MPG) dramatically sensitizes cells to alkylating agent-induced cytotoxicity. We recently demonstrated that this sensitivity is preceded by an increased production of AP sites and strand breaks, confirming that overexpre...

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Hauptverfasser: Rinne, M. L., He, Y., Pachkowski, B. F., Nakamura, J., Kelley, M. R.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2005
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1131935/
https://ncbi.nlm.nih.gov/pubmed/15905475
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gki601
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