ATM regulates 3-Methylpurine-DNA glycosylase and promotes therapeutic resistance to alkylating agents

Alkylating agents are a frontline therapy for the treatment of several aggressive cancers including pediatric glioblastoma, a lethal tumor in children. Unfortunately, many tumors are resistant to this therapy. We sought to identify ways of sensitizing tumor cells to alkylating agents while leaving n...

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Detalhes bibliográficos
Main Authors: Agnihotri, Sameer, Burrell, Kelly, Buczkowicz, Pawel, Remke, Marc, Golbourn, Brian, Chornenkyy, Yevgen, Gajadhar, Aaron, Fernandez, Nestor A., Clarke, Ian D., Barszczyk, Mark S., Pajovic, Sanja, Ternamian, Christian, Head, Renee, Sabha, Nesrin, Sobol, Robert W., Taylor, Michael D, Rutka, James T., Jones, Chris, Dirks, Peter B., Zadeh, Gelareh, Hawkins, Cynthia
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4184920/
https://ncbi.nlm.nih.gov/pubmed/25100205
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-14-0157
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