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ATM regulates 3-Methylpurine-DNA glycosylase and promotes therapeutic resistance to alkylating agents

Alkylating agents are a frontline therapy for the treatment of several aggressive cancers including pediatric glioblastoma, a lethal tumor in children. Unfortunately, many tumors are resistant to this therapy. We sought to identify ways of sensitizing tumor cells to alkylating agents while leaving n...

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Bibliografski detalji
Glavni autori: Agnihotri, Sameer, Burrell, Kelly, Buczkowicz, Pawel, Remke, Marc, Golbourn, Brian, Chornenkyy, Yevgen, Gajadhar, Aaron, Fernandez, Nestor A., Clarke, Ian D., Barszczyk, Mark S., Pajovic, Sanja, Ternamian, Christian, Head, Renee, Sabha, Nesrin, Sobol, Robert W., Taylor, Michael D, Rutka, James T., Jones, Chris, Dirks, Peter B., Zadeh, Gelareh, Hawkins, Cynthia
Format: Artigo
Jezik:Inglês
Izdano: 2014
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4184920/
https://ncbi.nlm.nih.gov/pubmed/25100205
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-14-0157
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