ATM regulates 3-Methylpurine-DNA glycosylase and promotes therapeutic resistance to alkylating agents

Alkylating agents are a frontline therapy for the treatment of several aggressive cancers including pediatric glioblastoma, a lethal tumor in children. Unfortunately, many tumors are resistant to this therapy. We sought to identify ways of sensitizing tumor cells to alkylating agents while leaving n...

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Autori principali: Agnihotri, Sameer, Burrell, Kelly, Buczkowicz, Pawel, Remke, Marc, Golbourn, Brian, Chornenkyy, Yevgen, Gajadhar, Aaron, Fernandez, Nestor A., Clarke, Ian D., Barszczyk, Mark S., Pajovic, Sanja, Ternamian, Christian, Head, Renee, Sabha, Nesrin, Sobol, Robert W., Taylor, Michael D, Rutka, James T., Jones, Chris, Dirks, Peter B., Zadeh, Gelareh, Hawkins, Cynthia
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2014
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4184920/
https://ncbi.nlm.nih.gov/pubmed/25100205
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-14-0157
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