Apak competes with p53 for direct binding to intron 1 of p53AIP1 to regulate apoptosis

The KRAB-type zinc-finger protein Apak was recently identified as a negative regulator of p53-mediated apoptosis. However, the mechanism of this selective regulation is not fully understood. Here, we show that Apak recognizes the TCTTN(2−30)TTGT consensus sequence through its zinc-fingers. This sequ...

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Detalhes bibliográficos
Main Authors: Yuan, Lin, Tian, Chunyan, Wang, Hongye, Song, Shanshan, Li, Deyang, Xing, Guichun, Yin, Yuxin, He, Fuchu, Zhang, Lingqiang
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2012
Assuntos:
Scientific Reports
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3321147/
https://ncbi.nlm.nih.gov/pubmed/22334068
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/embor.2012.10
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