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Apak competes with p53 for direct binding to intron 1 of p53AIP1 to regulate apoptosis
The KRAB-type zinc-finger protein Apak was recently identified as a negative regulator of p53-mediated apoptosis. However, the mechanism of this selective regulation is not fully understood. Here, we show that Apak recognizes the TCTTN(2−30)TTGT consensus sequence through its zinc-fingers. This sequ...
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| Hlavní autoři: | , , , , , , , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
Nature Publishing Group
2012
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3321147/ https://ncbi.nlm.nih.gov/pubmed/22334068 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/embor.2012.10 |
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