Smad Ubiquitylation Regulatory Factor 1/2 (Smurf1/2) Promotes p53 Degradation by Stabilizing the E3 Ligase MDM2

The tumor suppressor p53 protein is tightly regulated by a ubiquitin-proteasomal degradation mechanism. Several E3 ubiquitin ligases, including MDM2 (mouse double minute 2), have been reported to play an essential role in the regulation of p53 stability. However, it remains unclear how the activity...

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Detalhes bibliográficos
Main Authors: Nie, Jing, Xie, Ping, Liu, Lin, Xing, Guichun, Chang, Zhijie, Yin, Yuxin, Tian, Chunyan, He, Fuchu, Zhang, Lingqiang
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Protein Synthesis and Degradation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2906273/
https://ncbi.nlm.nih.gov/pubmed/20484049
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.126920
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