Pivotal Role of the C2 Domain of the Smurf1 Ubiquitin Ligase in Substrate Selection

The C2-WW-HECT-type ubiquitin ligases Smurf1 and Smurf2 play a critical role in embryogenesis and adult bone homeostasis via regulation of bone morphogenetic protein, Wnt, and RhoA signaling pathways. The intramolecular interaction between C2 and HECT domains autoinhibits the ligase activity of Smur...

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Hlavní autoři: Lu, Kefeng, Li, Ping, Zhang, Minghua, Xing, Guichun, Li, Xin, Zhou, Weihong, Bartlam, Mark, Zhang, Lingqiang, Rao, Zihe, He, Fuchu
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2011
Témata:
Protein Synthesis and Degradation
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3089529/
https://ncbi.nlm.nih.gov/pubmed/21402695
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.211979
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