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Pivotal Role of the C2 Domain of the Smurf1 Ubiquitin Ligase in Substrate Selection
The C2-WW-HECT-type ubiquitin ligases Smurf1 and Smurf2 play a critical role in embryogenesis and adult bone homeostasis via regulation of bone morphogenetic protein, Wnt, and RhoA signaling pathways. The intramolecular interaction between C2 and HECT domains autoinhibits the ligase activity of Smur...
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| Main Authors: | , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3089529/ https://ncbi.nlm.nih.gov/pubmed/21402695 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.211979 |
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