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Pivotal Role of the C2 Domain of the Smurf1 Ubiquitin Ligase in Substrate Selection

The C2-WW-HECT-type ubiquitin ligases Smurf1 and Smurf2 play a critical role in embryogenesis and adult bone homeostasis via regulation of bone morphogenetic protein, Wnt, and RhoA signaling pathways. The intramolecular interaction between C2 and HECT domains autoinhibits the ligase activity of Smur...

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書誌詳細
主要な著者: Lu, Kefeng, Li, Ping, Zhang, Minghua, Xing, Guichun, Li, Xin, Zhou, Weihong, Bartlam, Mark, Zhang, Lingqiang, Rao, Zihe, He, Fuchu
フォーマット: Artigo
言語:Inglês
出版事項: American Society for Biochemistry and Molecular Biology 2011
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3089529/
https://ncbi.nlm.nih.gov/pubmed/21402695
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.211979
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