Pivotal Role of the C2 Domain of the Smurf1 Ubiquitin Ligase in Substrate Selection

The C2-WW-HECT-type ubiquitin ligases Smurf1 and Smurf2 play a critical role in embryogenesis and adult bone homeostasis via regulation of bone morphogenetic protein, Wnt, and RhoA signaling pathways. The intramolecular interaction between C2 and HECT domains autoinhibits the ligase activity of Smur...

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Autori principali: Lu, Kefeng, Li, Ping, Zhang, Minghua, Xing, Guichun, Li, Xin, Zhou, Weihong, Bartlam, Mark, Zhang, Lingqiang, Rao, Zihe, He, Fuchu
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2011
Soggetti:
Protein Synthesis and Degradation
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3089529/
https://ncbi.nlm.nih.gov/pubmed/21402695
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.211979
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