CKIP-1 couples Smurf1 ubiquitin ligase with Rpt6 subunit of proteasome to promote substrate degradation

CKIP-1 is an activator of the Smurf1 ubiquitin ligase acting to promote the ubiquitylation of Smad5 and MEKK2. The mechanisms involved in the recognition and degradation of these substrates by the proteasome remain unclear. Here, we show that CKIP-1, through its leucine zipper, interacts directly wi...

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Detalhes bibliográficos
Main Authors: Wang, Yifang, Nie, Jing, Wang, Yiwu, Zhang, Luo, Lu, Kefeng, Xing, Guichun, Xie, Ping, He, Fuchu, Zhang, Lingqiang
Formato: Artigo
Idioma:Inglês
Publicado em: European Molecular Biology Organization 2012
Assuntos:
Scientific Reports
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3492711/
https://ncbi.nlm.nih.gov/pubmed/23032291
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/embor.2012.144
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