Pivotal Role of the C2 Domain of the Smurf1 Ubiquitin Ligase in Substrate Selection

The C2-WW-HECT-type ubiquitin ligases Smurf1 and Smurf2 play a critical role in embryogenesis and adult bone homeostasis via regulation of bone morphogenetic protein, Wnt, and RhoA signaling pathways. The intramolecular interaction between C2 and HECT domains autoinhibits the ligase activity of Smur...

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Bibliographische Detailangaben
Hauptverfasser: Lu, Kefeng, Li, Ping, Zhang, Minghua, Xing, Guichun, Li, Xin, Zhou, Weihong, Bartlam, Mark, Zhang, Lingqiang, Rao, Zihe, He, Fuchu
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2011
Schlagworte:
Protein Synthesis and Degradation
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3089529/
https://ncbi.nlm.nih.gov/pubmed/21402695
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.211979
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