Pivotal Role of the C2 Domain of the Smurf1 Ubiquitin Ligase in Substrate Selection

The C2-WW-HECT-type ubiquitin ligases Smurf1 and Smurf2 play a critical role in embryogenesis and adult bone homeostasis via regulation of bone morphogenetic protein, Wnt, and RhoA signaling pathways. The intramolecular interaction between C2 and HECT domains autoinhibits the ligase activity of Smur...

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Detaylı Bibliyografya
Asıl Yazarlar: Lu, Kefeng, Li, Ping, Zhang, Minghua, Xing, Guichun, Li, Xin, Zhou, Weihong, Bartlam, Mark, Zhang, Lingqiang, Rao, Zihe, He, Fuchu
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Biochemistry and Molecular Biology 2011
Konular:
Protein Synthesis and Degradation
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3089529/
https://ncbi.nlm.nih.gov/pubmed/21402695
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.211979
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