Smad Ubiquitylation Regulatory Factor 1/2 (Smurf1/2) Promotes p53 Degradation by Stabilizing the E3 Ligase MDM2

The tumor suppressor p53 protein is tightly regulated by a ubiquitin-proteasomal degradation mechanism. Several E3 ubiquitin ligases, including MDM2 (mouse double minute 2), have been reported to play an essential role in the regulation of p53 stability. However, it remains unclear how the activity...

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Главные авторы: Nie, Jing, Xie, Ping, Liu, Lin, Xing, Guichun, Chang, Zhijie, Yin, Yuxin, Tian, Chunyan, He, Fuchu, Zhang, Lingqiang
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Biochemistry and Molecular Biology 2010
Предметы:
Protein Synthesis and Degradation
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2906273/
https://ncbi.nlm.nih.gov/pubmed/20484049
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.126920
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