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Design, synthesis, modeling, biological evaluation and photoaffinity labeling studies of novel series of photoreactive benzamide probes for histone deacetylase 2

The design, modeling, synthesis, biological evaluation of a novel series of photoreactive benzamide probes for class I HDAC isoforms is reported. The probes are potent and selective for HDAC1 and 2 and are efficient in crosslinking to HDAC2 as demonstrated by photolabeling experiments. The probes ex...

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Bibliografski detalji
Glavni autori: Vaidya, Aditya Sudheer, Karumudi, Bhargava, Mendonca, Emma, Madriaga, Antonett, Abdelkarim, Hazem, van Breemen, Richard B., Petukhov, Pavel A.
Format: Artigo
Jezik:Inglês
Izdano: 2012
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3401313/
https://ncbi.nlm.nih.gov/pubmed/22771007
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2012.06.017
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