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Design, Synthesis, Molecular Modeling, and Biological Evaluation of Novel Amine-based Histone Deacetylase Inhibitors
Histone deacetylases (HDACs) are promising drug targets for a variety of therapeutic applications. Here we describe the design, synthesis, biological evaluation in cellular models of cancer, and preliminary drug metabolism and pharmacokinetic studies (DMPK) of a series of secondary and tertiary N-su...
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| Udgivet i: | ChemMedChem |
|---|---|
| Main Authors: | , , , , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2017
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5881582/ https://ncbi.nlm.nih.gov/pubmed/29080240 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.201700449 |
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