Design, Synthesis, Molecular Modeling, and Biological Evaluation of Novel Amine-based Histone Deacetylase Inhibitors

Histone deacetylases (HDACs) are promising drug targets for a variety of therapeutic applications. Here we describe the design, synthesis, biological evaluation in cellular models of cancer, and preliminary drug metabolism and pharmacokinetic studies (DMPK) of a series of secondary and tertiary N-su...

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Détails bibliographiques
Publié dans:ChemMedChem
Auteurs principaux: Abdelkarim, Hazem, Neelarapu, Raghupathi, Madriaga, Antonett, Vaidya, Aditya S., Kastrati, Irida, Wang, Yue-ting, Taha, Taha Y., Thatcher, Gregory R. J., Frasor, Jonna, Petukhov, Pavel A.
Format: Artigo
Langue:Inglês
Publié: 2017
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5881582/
https://ncbi.nlm.nih.gov/pubmed/29080240
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.201700449
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