Design, Synthesis, and Biological Evaluation of Tetrahydroisoquinoline-Based Histone Deacetylase 8 Selective Inhibitors

[Image: see text] Histone deacetylase 8 (HDAC8) is a promising drug target for multiple therapeutic applications. Here, we describe the modeling, design, synthesis, and biological evaluation of a novel series of C1-substituted tetrahydroisoquinoline (TIQ)-based HDAC8 inhibitors. Minimization of entr...

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Publicado en:ACS Med Chem Lett
Autores principales: Taha, Taha Y., Aboukhatwa, Shaimaa M., Knopp, Rachel C., Ikegaki, Naohiko, Abdelkarim, Hazem, Neerasa, Jayaprakash, Lu, Yunlong, Neelarapu, Raghupathi, Hanigan, Thomas W., Thatcher, Gregory R. J., Petukhov, Pavel A.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Chemical Society 2017
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5554898/
https://ncbi.nlm.nih.gov/pubmed/28835796
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.7b00126
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