Structurally Diverse Histone Deacetylase Photoreactive Probes: Design, Synthesis, and Photolabeling Studies in Live Cells and Tissue

Histone deacetylase (HDAC) activity is modulated in vivo by post-translational modifications and formation of multiprotein complexes. Novel chemical tools to study how these factors affect engagement of HDAC isoforms by HDAC inhibitors (HDACi) in cells and tissues are needed. In this study, a synthe...

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Publicado no:ChemMedChem
Main Authors: Aboukhatwa, Shaimaa M., Hanigan, Thomas W., Taha, Taha Y., Neerasa, Jayaprakash, Ranjan, Rajeev, El-Bastawissy, Eman E., Elkersh, Mohamed A., El-Moselhy, Tarek F., Frasor, Jonna, Mahmud, Nadim, McLachlan, Alan, Petukhov, Pavel A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6548601/
https://ncbi.nlm.nih.gov/pubmed/30921497
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.201900114
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