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Histone deacetylase inhibitor-based chromatin precipitation for identification of targeted genomic loci

Histone deacetylase (HDAC) catalyzes the removal of acetyl marks from histones, effectively regulating gene expression. Genome wide chromatin immunoprecipitation (ChIP) studies have shown HDACs are present on numerous active and repressed genes. However, HDAC inhibitors (HDACi) only regulate a small...

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Bibliografske podrobnosti
izdano v:J Biol Methods
Main Authors: Hanigan, Thomas W., Danes, Jeanne M., Taha, Taha Y., Frasor, Jonna, Petukhov, Pavel A.
Format: Artigo
Jezik:Inglês
Izdano: Journal of Biological Methods 2018
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5909381/
https://ncbi.nlm.nih.gov/pubmed/29682593
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.14440/jbm.2018.216
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