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Divergent JNK Phosphorylation of HDAC3 in Triple Negative Breast Cancer Cells Determines HDAC Inhibitor Binding and Selectivity
Histone deacetylase (HDAC) catalytic activity is regulated by formation of co-regulator complexes and post-translational modification. Whether these mechanisms are transformed in cancer and how this affects the binding and selectivity of HDAC inhibitors (HDACi) is unclear. In this study, we develope...
Αποθηκεύτηκε σε:
| Τόπος έκδοσης: | Cell Chem Biol |
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| Κύριοι συγγραφείς: | , , , , |
| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
2017
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| Θέματα: | |
| Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5693607/ https://ncbi.nlm.nih.gov/pubmed/28943357 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2017.08.015 |
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