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Divergent JNK Phosphorylation of HDAC3 in Triple Negative Breast Cancer Cells Determines HDAC Inhibitor Binding and Selectivity

Histone deacetylase (HDAC) catalytic activity is regulated by formation of co-regulator complexes and post-translational modification. Whether these mechanisms are transformed in cancer and how this affects the binding and selectivity of HDAC inhibitors (HDACi) is unclear. In this study, we develope...

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Publicado en:Cell Chem Biol
Autores principales: Hanigan, Thomas W., Aboukhatwa, Shaimaa M., Taha, Taha, Frasor, Jonna, Petukhov, Pavel A.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2017
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5693607/
https://ncbi.nlm.nih.gov/pubmed/28943357
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2017.08.015
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