Structurally Diverse Histone Deacetylase Photoreactive Probes: Design, Synthesis, and Photolabeling Studies in Live Cells and Tissue

Histone deacetylase (HDAC) activity is modulated in vivo by post-translational modifications and formation of multiprotein complexes. Novel chemical tools to study how these factors affect engagement of HDAC isoforms by HDAC inhibitors (HDACi) in cells and tissues are needed. In this study, a synthe...

Descripción completa

Guardado en:
Detalles Bibliográficos
Publicado en:ChemMedChem
Autores principales: Aboukhatwa, Shaimaa M., Hanigan, Thomas W., Taha, Taha Y., Neerasa, Jayaprakash, Ranjan, Rajeev, El-Bastawissy, Eman E., Elkersh, Mohamed A., El-Moselhy, Tarek F., Frasor, Jonna, Mahmud, Nadim, McLachlan, Alan, Petukhov, Pavel A.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2019
Materias:
Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6548601/
https://ncbi.nlm.nih.gov/pubmed/30921497
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.201900114
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!

Ejemplares similares