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Novel histone deacetylase 8 ligands without a zinc chelating group: exploring an “upside-down” binding pose
A novel series of HDAC8 inhibitors without a zinc-chelating hydroxamic acid moiety is reported. Photoaffinity labeling and molecular modeling studies suggest that these ligands are likely to bind in an “upside-down” fashion in a secondary binding site proximal to the main catalytic site. The most po...
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| Auteurs principaux: | , , , , , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2012
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3472134/ https://ncbi.nlm.nih.gov/pubmed/23010266 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2012.08.104 |
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