A carregar...
Novel histone deacetylase 8 ligands without a zinc chelating group: exploring an “upside-down” binding pose
A novel series of HDAC8 inhibitors without a zinc-chelating hydroxamic acid moiety is reported. Photoaffinity labeling and molecular modeling studies suggest that these ligands are likely to bind in an “upside-down” fashion in a secondary binding site proximal to the main catalytic site. The most po...
Na minha lista:
| Main Authors: | , , , , , , , , |
|---|---|
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
|
| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3472134/ https://ncbi.nlm.nih.gov/pubmed/23010266 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2012.08.104 |
| Tags: |
Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!
|