Photoreactive “Nanorulers” Detect a Novel Conformation of Full length HDAC3-SMRT Complex in Solution

Histone deacetylase 3 (HDAC3) is a promising epigenetic drug target for multiple therapeutic applications. Direct interaction between the Deacetylase Activating Domain of the silencing mediator for retinoid or thyroid hormone receptors (SMRT-DAD) is required for activation of enzymatic activity of H...

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Main Authors: Abdelkarim, Hazem, Brunsteiner, Michael, Neelarapu, Raghupathi, Bai, He, Madriaga, Antonett, van Breemen, Richard B., Blond, Sylvie Y., Gaponenko, Vadim, Petukhov, Pavel A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3880688/
https://ncbi.nlm.nih.gov/pubmed/24010878
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cb400601g
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