Acyclic Immucillin Phosphonates: Second generation inhibitors of Plasmodium falciparum hypoxanthine-guanine-xanthine phosphoribosyltransferase

Plasmodium falciparum, the primary cause of deaths from malaria, is a purine auxotroph and relies on hypoxanthine salvage from the host purine pool. Purine starvation as an antimalarial target has been validated by inhibition of purine nucleoside phosphorylase. Hypoxanthine depletion kills Plasmodiu...

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Main Authors: Hazleton, Keith Z., Ho, Meng-Chiao, Cassera, Maria B., Clinch, Keith, Crump, Douglas R., Rosario, Irving, Merino, Emilio F., Almo, Steve C., Tyler, Peter C., Schramm, Vern L.
Format: Artigo
Jezik:Inglês
Izdano: 2012
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3397391/
https://ncbi.nlm.nih.gov/pubmed/22726686
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2012.04.012
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