Acyclic Immucillin Phosphonates: Second generation inhibitors of Plasmodium falciparum hypoxanthine-guanine-xanthine phosphoribosyltransferase

Plasmodium falciparum, the primary cause of deaths from malaria, is a purine auxotroph and relies on hypoxanthine salvage from the host purine pool. Purine starvation as an antimalarial target has been validated by inhibition of purine nucleoside phosphorylase. Hypoxanthine depletion kills Plasmodiu...

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Bibliographic Details
Main Authors: Hazleton, Keith Z., Ho, Meng-Chiao, Cassera, Maria B., Clinch, Keith, Crump, Douglas R., Rosario, Irving, Merino, Emilio F., Almo, Steve C., Tyler, Peter C., Schramm, Vern L.
Format: Artigo
Language:Inglês
Published: 2012
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3397391/
https://ncbi.nlm.nih.gov/pubmed/22726686
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2012.04.012
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