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Sumoylation of MDC1 is important for proper DNA damage response

In response to DNA damage, many DNA damage factors, such as MDC1 and 53BP1, redistribute to sites of DNA damage. The mechanism governing the turnover of these factors at DNA damage sites, however, remains enigmatic. Here, we show that MDC1 is sumoylated following DNA damage, and the sumoylation of M...

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Autores principales: Luo, Kuntian, Zhang, Haoxing, Wang, Liewei, Yuan, Jian, Lou, Zhenkun
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group 2012
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3395099/
https://ncbi.nlm.nih.gov/pubmed/22635276
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2012.158
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