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MDC1 regulates intra-S-phase checkpoint by targeting NBS1 to DNA double-strand breaks

The product of the Nijmegen breakage syndrome gene (NBS1) plays crucial roles in DNA damage response through its association with many proteins, including MRE11 and RAD50. However, it remains to be determined exactly how NBS1 accumulates at or near DNA double-strand breaks. Here we report that MDC1...

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Detalhes bibliográficos
Main Authors: Wu, Liming, Luo, Kuntian, Lou, Zhenkun, Chen, Junjie
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2516250/
https://ncbi.nlm.nih.gov/pubmed/18678890
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0802885105
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