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MDC1 regulates intra-S-phase checkpoint by targeting NBS1 to DNA double-strand breaks

The product of the Nijmegen breakage syndrome gene (NBS1) plays crucial roles in DNA damage response through its association with many proteins, including MRE11 and RAD50. However, it remains to be determined exactly how NBS1 accumulates at or near DNA double-strand breaks. Here we report that MDC1...

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Bibliografische gegevens
Hoofdauteurs: Wu, Liming, Luo, Kuntian, Lou, Zhenkun, Chen, Junjie
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: National Academy of Sciences 2008
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2516250/
https://ncbi.nlm.nih.gov/pubmed/18678890
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0802885105
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