Mdc1 couples DNA double-strand break recognition by Nbs1 with its H2AX-dependent chromatin retention

Mdc1/NFBD1 controls cellular responses to DNA damage, in part via interacting with the Mre11–Rad50–Nbs1 complex that is involved in the recognition, signalling, and repair of DNA double-strand breaks (DSBs). Here, we show that in live human cells, the transient interaction of Nbs1 with DSBs and its...

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Pubblicato in:EMBO J
Autori principali: Lukas, Claudia, Melander, Fredrik, Stucki, Manuel, Falck, Jacob, Bekker-Jensen, Simon, Goldberg, Michal, Lerenthal, Yaniv, Jackson, Stephen P, Bartek, Jiri, Lukas, Jiri
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2004
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Article
Accesso online:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC449779/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15201865/
https://ncbi.nlm.nih.govhttps://doi.org/10.1038/sj.emboj.7600269
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