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Mdc1 couples DNA double-strand break recognition by Nbs1 with its H2AX-dependent chromatin retention
Mdc1/NFBD1 controls cellular responses to DNA damage, in part via interacting with the Mre11–Rad50–Nbs1 complex that is involved in the recognition, signalling, and repair of DNA double-strand breaks (DSBs). Here, we show that in live human cells, the transient interaction of Nbs1 with DSBs and its...
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| Hoofdauteurs: | , , , , , , , , , |
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| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
Nature Publishing Group
2004
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC449779/ https://ncbi.nlm.nih.gov/pubmed/15201865 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7600269 |
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