Phosphorylation of SDT repeats in the MDC1 N terminus triggers retention of NBS1 at the DNA damage–modified chromatin

DNA double-strand breaks (DSBs) trigger accumulation of the MRE11–RAD50–Nijmegen breakage syndrome 1 (NBS1 [MRN]) complex, whose retention on the DSB-flanking chromatin facilitates survival. Chromatin retention of MRN requires the MDC1 adaptor protein, but the mechanism behind the MRN–MDC1 interacti...

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Bibliographic Details
Main Authors: Melander, Fredrik, Bekker-Jensen, Simon, Falck, Jacob, Bartek, Jiri, Mailand, Niels, Lukas, Jiri
Format: Artigo
Language:Inglês
Published: The Rockefeller University Press 2008
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Research Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2315670/
https://ncbi.nlm.nih.gov/pubmed/18411307
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200708210
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