Phospho-dependent interactions between NBS1 and MDC1 mediate chromatin retention of the MRN complex at sites of DNA damage

Mammalian cells respond to DNA double-strand breaks (DSBs) by recruiting DNA repair and cell-cycle checkpoint proteins to such sites. Central to these DNA damage response (DDR) events is the DNA damage mediator protein MDC1. MDC1 interacts with several DDR proteins, including the MRE11–RAD50–NBS1 (M...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Chapman, J Ross, Jackson, Stephen P
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group 2008
Pynciau:
Scientific Report
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2442910/
https://ncbi.nlm.nih.gov/pubmed/18583988
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/embor.2008.103
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