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Dynamic assembly and sustained retention of 53BP1 at the sites of DNA damage are controlled by Mdc1/NFBD1

53BP1 is a key component of the genome surveillance network activated by DNA double strand breaks (DSBs). Despite its known accumulation at the DSB sites, the spatiotemporal aspects of 53BP1 interaction with DSBs and the role of other DSB regulators in this process remain unclear. Here, we used real...

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Autors principals: Bekker-Jensen, Simon, Lukas, Claudia, Melander, Fredrik, Bartek, Jiri, Lukas, Jiri
Format: Artigo
Idioma:Inglês
Publicat: The Rockefeller University Press 2005
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2171401/
https://ncbi.nlm.nih.gov/pubmed/16009723
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200503043
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