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Distinct roles of chromatin-associated factors MDC1 and 53BP1 in mammalian double strand break repair
Phosphorylated histone H2AX (“γ-H2AX”) recruits MDC1, 53BP1 and BRCA1 to chromatin near a double strand break (DSB) and facilitates efficient repair of the break. It is unclear to what extent γ-H2AX associated proteins act in concert and to what extent their functions within γ-H2AX chromatin are dis...
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| Autors principals: | , , , , , , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2007
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2275782/ https://ncbi.nlm.nih.gov/pubmed/18158901 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2007.12.005 |
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