Distinct roles of chromatin-associated factors MDC1 and 53BP1 in mammalian double strand break repair

Phosphorylated histone H2AX (“γ-H2AX”) recruits MDC1, 53BP1 and BRCA1 to chromatin near a double strand break (DSB) and facilitates efficient repair of the break. It is unclear to what extent γ-H2AX associated proteins act in concert and to what extent their functions within γ-H2AX chromatin are dis...

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Main Authors: Xie, Anyong, Hartlerode, Andrea, Stucki, Manuel, Odate, Shobu, Puget, Nadine, Kwok, Amy, Nagaraju, Ganesh, Yan, Catherine, Alt, Frederick W., Chen, Junjie, Jackson, Stephen P, Scully, Ralph
Formato: Artigo
Idioma:Inglês
Publicado em: 2007
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2275782/
https://ncbi.nlm.nih.gov/pubmed/18158901
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2007.12.005
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