Impact of Histone H4 Lysine 20 Methylation on 53BP1 Responses to Chromosomal Double Strand Breaks

Recruitment of 53BP1 to chromatin flanking double strand breaks (DSBs) requires γH2AX/MDC1/RNF8-dependent ubiquitination of chromatin and interaction of 53BP1 with histone H4 methylated on lysine 20 (H4K20me). Several histone methyltransferases have been implicated in 53BP1 recruitment, but their qu...

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Main Authors: Hartlerode, Andrea J., Guan, Yinghua, Rajendran, Anbazhagan, Ura, Kiyoe, Schotta, Gunnar, Xie, Anyong, Shah, Jagesh V., Scully, Ralph
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2012
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3509127/
https://ncbi.nlm.nih.gov/pubmed/23209566
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0049211
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