Dephosphorylation enables the recruitment of 53BP1 to double-strand DNA breaks

Excluding 53BP1 from chromatin is required to attenuate the DNA damage response during mitosis, yet the functional relevance and regulation of this exclusion is unclear. Here we show that 53BP1 is phosphorylated during mitosis on two residues, T1609 and S1618, located in its well-conserved ubiquitin...

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Detalhes bibliográficos
Principais autores: Lee, Dong-Hyun, Acharya, Sanket S., Kwon, Mijung, Drane, Pascal, Guan, Yinghua, Adelmant, Guillaume, Kalev, Peter, Shah, Jagesh, Pellman, David, Marto, Jarrod A., Chowdhury, Dipanjan
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4030556/
https://ncbi.nlm.nih.gov/pubmed/24703952
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2014.03.020
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