Dephosphorylation enables the recruitment of 53BP1 to double-strand DNA breaks

Excluding 53BP1 from chromatin is required to attenuate the DNA damage response during mitosis, yet the functional relevance and regulation of this exclusion is unclear. Here we show that 53BP1 is phosphorylated during mitosis on two residues, T1609 and S1618, located in its well-conserved ubiquitin...

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Hauptverfasser: Lee, Dong-Hyun, Acharya, Sanket S., Kwon, Mijung, Drane, Pascal, Guan, Yinghua, Adelmant, Guillaume, Kalev, Peter, Shah, Jagesh, Pellman, David, Marto, Jarrod A., Chowdhury, Dipanjan
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2014
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4030556/
https://ncbi.nlm.nih.gov/pubmed/24703952
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2014.03.020
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