A mitotic CDK5-PP4 phospho-signaling cascade primes 53BP1 for DNA repair in G1

Mitotic cells attenuate the DNA damage response (DDR) by phosphorylating 53BP1, a critical DDR mediator, to prevent its localization to damaged chromatin. Timely dephosphorylation of 53BP1 is critical for genome integrity, as premature recruitment of 53BP1 to DNA lesions impairs mitotic fidelity. Pr...

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Udgivet i:Nat Commun
Main Authors: Zheng, Xiao-Feng, Acharya, Sanket S., Choe, Katherine N., Nikhil, Kumar, Adelmant, Guillaume, Satapathy, Shakti Ranjan, Sharma, Samanta, Viccaro, Keith, Rana, Sandeep, Natarajan, Amarnath, Sicinski, Peter, Marto, Jarrod A., Shah, Kavita, Chowdhury, Dipanjan
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6751209/
https://ncbi.nlm.nih.gov/pubmed/31534152
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-12084-x
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