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A single ligand is sufficient to activate EGFR dimers

Crystal structures of human epidermal growth factor receptor (EGFR) with bound ligand revealed symmetric, doubly ligated receptor dimers thought to represent physiologically active states. Such complexes fail to rationalize negative cooperativity of epidermal growth factor (EGF) binding to EGFR and...

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Autors principals: Liu, Ping, Cleveland, Thomas E., Bouyain, Samuel, Byrne, Patrick O., Longo, Patti A., Leahy, Daniel J.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2012
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3390854/
https://ncbi.nlm.nih.gov/pubmed/22699492
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1201114109
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