Phosphorylated EGFR Dimers Are Not Sufficient to Activate Ras

Growth factor binding to EGFR drives conformational changes that promote homodimerization and transphosphorylation, followed by adaptor recruitment, oligomerization, and signaling through Ras. Whether specific receptor conformations and oligomerization states are necessary for efficient activation o...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Cell Rep
Prif Awduron: Liang, Samantha I., van Lengerich, Bettina, Eichel, Kelsie, Cha, Minkwon, Patterson, David M., Yoon, Tae-Young, von Zastrow, Mark, Jura, Natalia, Gartner, Zev J.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2018
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5916813/
https://ncbi.nlm.nih.gov/pubmed/29514089
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2018.02.031
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