Phosphorylated EGFR Dimers Are Not Sufficient to Activate Ras

Growth factor binding to EGFR drives conformational changes that promote homodimerization and transphosphorylation, followed by adaptor recruitment, oligomerization, and signaling through Ras. Whether specific receptor conformations and oligomerization states are necessary for efficient activation o...

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Detalhes bibliográficos
Publicado no:Cell Rep
Main Authors: Liang, Samantha I., van Lengerich, Bettina, Eichel, Kelsie, Cha, Minkwon, Patterson, David M., Yoon, Tae-Young, von Zastrow, Mark, Jura, Natalia, Gartner, Zev J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5916813/
https://ncbi.nlm.nih.gov/pubmed/29514089
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2018.02.031
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