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Phosphorylated EGFR Dimers Are Not Sufficient to Activate Ras
Growth factor binding to EGFR drives conformational changes that promote homodimerization and transphosphorylation, followed by adaptor recruitment, oligomerization, and signaling through Ras. Whether specific receptor conformations and oligomerization states are necessary for efficient activation o...
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| Publicado no: | Cell Rep |
|---|---|
| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5916813/ https://ncbi.nlm.nih.gov/pubmed/29514089 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2018.02.031 |
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