Phosphorylated EGFR Dimers Are Not Sufficient to Activate Ras

Growth factor binding to EGFR drives conformational changes that promote homodimerization and transphosphorylation, followed by adaptor recruitment, oligomerization, and signaling through Ras. Whether specific receptor conformations and oligomerization states are necessary for efficient activation o...

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Foilsithe in:Cell Rep
Main Authors: Liang, Samantha I., van Lengerich, Bettina, Eichel, Kelsie, Cha, Minkwon, Patterson, David M., Yoon, Tae-Young, von Zastrow, Mark, Jura, Natalia, Gartner, Zev J.
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2018
Ábhair:
Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5916813/
https://ncbi.nlm.nih.gov/pubmed/29514089
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2018.02.031
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