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EGFR phosphorylates FAM129B to promote Ras activation

Ras GTPase-activating proteins (GAPs) are important regulators for Ras activation, which is instrumental in tumor development. However, the mechanism underlying this regulation remains elusive. We demonstrate here that activated EGFR phosphorylates the Y593 residue of the protein known as family wit...

תיאור מלא

שמור ב:
מידע ביבליוגרפי
הוצא לאור ב:Proc Natl Acad Sci U S A
Main Authors: Ji, Haitao, Lee, Jong-Ho, Wang, Yugang, Pang, Yilin, Zhang, Tao, Xia, Yan, Zhong, Lianjin, Lyu, Jianxin, Lu, Zhimin
פורמט: Artigo
שפה:Inglês
יצא לאור: National Academy of Sciences 2016
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC4725532/
https://ncbi.nlm.nih.gov/pubmed/26721396
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1517112113
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