EGFR-Phosphorylated Platelet Isoform of Phosphofructokinase 1 Promotes PI3K Activation

EGFR activates phosphatidylinositide 3-kinase (PI3K), but the mechanism underlying this activation is not completely understood. We demonstrated here that EGFR activation resulted in lysine acetyltransferase 5 (KAT5)-mediated K395 acetylation of the platelet isoform of phosphofructokinase 1 (PFKP) a...

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Bibliografiske detaljer
Udgivet i:Mol Cell
Main Authors: Lee, Jong-Ho, Liu, Rui, Li, Jing, Wang, Yugang, Tan, Lin, Li, Xin-Jian, Qian, Xu, Zhang, Chuanbao, Xia, Yan, Xu, Daqian, Guo, Wei, Ding, Zhiyong, Du, Linyong, Zheng, Yanhua, Chen, Qianming, Lorenzi, Philip L., Mills, Gordon B, Jiang, Tao, Lu, Zhimin
Format: Artigo
Sprog:Inglês
Udgivet: 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6114939/
https://ncbi.nlm.nih.gov/pubmed/29677490
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2018.03.018
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