The platelet isoform of phosphofructokinase contributes to metabolic reprogramming and maintains cell proliferation in clear cell renal cell carcinoma

Metabolic alterations underlying clear cell renal cell carcinoma (ccRCC) progression include aerobic glycolysis, increased pentose phosphate pathway activity and reduced oxidative phosphorylation. Phosphofructokinase (PFK), a key enzyme of the glycolytic pathway, has L, M, and P isoforms with differ...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Wang, Jun, Zhang, Ping, Zhong, Jie, Tan, Mingyue, Ge, Jifu, Tao, Le, Li, Yakui, Zhu, Yemin, Wu, Lifang, Qiu, Jianxin, Tong, Xuemei
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2016
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5053638/
https://ncbi.nlm.nih.gov/pubmed/27049827
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.8382
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