Stabilization of phosphofructokinase 1 platelet isoform by AKT promotes tumorigenesis

Phosphofructokinase 1 (PFK1) plays a critical role in glycolysis; however, its role and regulation in tumorigenesis are not well understood. Here, we demonstrate that PFK1 platelet isoform (PFKP) is the predominant PFK1 isoform in human glioblastoma cells and its expression correlates with total PFK...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Lee, Jong-Ho, Liu, Rui, Li, Jing, Zhang, Chuanbao, Wang, Yugang, Cai, Qingsong, Qian, Xu, Xia, Yan, Zheng, Yanhua, Piao, Yuji, Chen, Qianming, de Groot, John F., Jiang, Tao, Lu, Zhimin
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5643558/
https://ncbi.nlm.nih.gov/pubmed/29038421
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-00906-9
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