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A single ligand is sufficient to activate EGFR dimers
Crystal structures of human epidermal growth factor receptor (EGFR) with bound ligand revealed symmetric, doubly ligated receptor dimers thought to represent physiologically active states. Such complexes fail to rationalize negative cooperativity of epidermal growth factor (EGF) binding to EGFR and...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3390854/ https://ncbi.nlm.nih.gov/pubmed/22699492 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1201114109 |
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