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EGFR ligands differentially stabilize receptor dimers to specify signaling kinetics
Epidermal growth factor receptor (EGFR) regulates many crucial cellular programs, with seven different activating ligands shaping cell signaling in distinct ways. Using crystallography and other approaches, we show how the EGFR ligands epiregulin (EREG) and epigen (EPGN) stabilize different dimeric...
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| Udgivet i: | Cell |
|---|---|
| Main Authors: | , , , , , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2017
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5650921/ https://ncbi.nlm.nih.gov/pubmed/28988771 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2017.09.017 |
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